/reference/drugs/muscle-relaxants

Muscle Relaxants & Reversals

Sux, roc, vec, cis, sugammadex, neostigmine

Launch catalog target: 9 drugs. 4 with full clinical detail below.

Succinylcholine

Depolarizing neuromuscular blocker

Acetylcholine receptor agonist at the NMJ; sustained depolarization → fasciculations → flaccid paralysis. Hydrolyzed by plasma cholinesterase.

Rocuronium

Zemuron

Aminosteroid non-depolarizing muscle relaxant

Competitive antagonist at the NMJ nicotinic receptor.

Sugammadex

Bridion

Modified γ-cyclodextrin selective relaxant binding agent

Encapsulates rocuronium > vecuronium > pancuronium in 1:1 complex. No effect on cisatracurium, atracurium, sux.

Cisatracurium

Nimbex

Benzylisoquinolinium non-depolarizing neuromuscular blocker (intermediate duration)

Competitive antagonist at the post-synaptic nicotinic ACh receptor at the neuromuscular junction. Single cis-cis isomer of atracurium (4× more potent, lower laudanosine production).

Education only — not a substitute for current package inserts or clinical judgment. Always confirm doses.