Sugammadex
Bridion
Modified γ-cyclodextrin selective relaxant binding agent
Encapsulates rocuronium > vecuronium > pancuronium in 1:1 complex. No effect on cisatracurium, atracurium, sux.
Indications
- •Reversal of rocuronium / vecuronium NMB
- •Emergency reversal of failed RSI
Dosing
| Context | Adult | Pediatric |
|---|---|---|
| Routine reversal (TOF 2+) | 2 mg/kg IV | 2 mg/kg IV (ages 2+) |
| Deep block (PTC ≥ 1, no TOF) | 4 mg/kg IV | — |
| Immediate emergency reversal | 16 mg/kg IV | — |
Pharmacokinetics
Onset 1–3 min. Renally excreted; ESRD prolonged clearance (still effective).
Side effects
- !Anaphylaxis (~1:2,500 to 1:20,000)
- !Bradycardia/asystole (rare)
- !Hormonal contraceptive interaction — counsel 7 days alternative contraception
- !Coagulation prolongation (small ↑ in PT/aPTT, no clinical bleeding)
Contraindications
- ×Known sugammadex allergy
Clinical pearls
- ★Re-paralysis with roc/vec ineffective for 24 h post-sugammadex; use cis or non-aminosteroid.
- ★ESRD: works fine; sugammadex-roc complex slowly excreted but no toxicity.
- ★Quantitative TOF should still be confirmed even after 4 mg/kg deep dose.
Education only — confirm against current package inserts and institutional protocols. Doses assume normal organ function unless otherwise noted.