/reference/drugs/coagulation
Heparin, enoxaparin, warfarin, DOACs, protamine, andexanet, idarucizumab, TXA, DDAVP
Indirect thrombin inhibitor
Activates antithrombin → inactivates IIa (thrombin) and Xa.
Antifibrinolytic (lysine analog)
Reversibly binds plasminogen, blocking conversion to plasmin → preserves fibrin clot.
Heparin antagonist
Strongly basic (positive-charge) protein binds to highly acidic (negative-charge) heparin → inactive ionic complex → renal excretion. 1 mg protamine neutralizes ~100 units heparin.
Synthetic vasopressin V2-receptor agonist
Selective V2 agonist (renal water retention + Factor VIII/vWF release from endothelial Weibel-Palade bodies). NO V1 vasopressor activity at therapeutic dose.