Pantoprazole
Protonix
Proton pump inhibitor
Irreversibly inhibits the gastric H⁺/K⁺-ATPase (proton pump) → ↓ gastric acid secretion + volume.
Indications
- •Aspiration prophylaxis (raise gastric pH, reduce volume — high-risk/OB, given the night before + morning of)
- •GI bleeding (high-dose infusion)
- •GERD / stress-ulcer prophylaxis
Dosing
| Context | Adult | Pediatric |
|---|---|---|
| Aspiration prophylaxis | 40 mg IV/PO (most effective if a dose is given the evening before + morning of surgery) | — |
| GI bleed | 80 mg IV bolus, then 8 mg/hr infusion | — |
Pharmacokinetics
Onset slower than H2 blockers/citrate (needs to act on active pumps) — timing matters. Hepatic CYP2C19.
