/reference/drugs/others

Others

Dantrolene, lipid emulsion 20%, sugammadex, vasopressin, nitric oxide

Dantrolene

Skeletal muscle ryanodine receptor antagonist

Blocks RYR1 (ryanodine receptor) → ↓ Ca²⁺ release from sarcoplasmic reticulum → muscle relaxation. The only drug for malignant hyperthermia.

Lipid Emulsion 20%

Intralipid

Lipid resuscitation agent

Theory: 'Lipid sink' sequesters lipophilic drugs (especially LAs), shifts to better Ca²⁺ handling, fatty acid metabolic support.

Hydroxocobalamin

Cyanokit

Cyanide antidote / NO scavenger

Vitamin B12a precursor; cyanide binds to cobalt center of hydroxocobalamin → forms cyanocobalamin (B12) → renal excretion. Also scavenges nitric oxide → vasoconstriction.

Education only — not a substitute for current package inserts or clinical judgment. Always confirm doses.