Thrombolytics / Fibrinolytics

Alteplase (tPA), tenecteplase (TNK)

Recombinant tissue plasminogen activator (fibrinolytic)

Converts fibrin-bound plasminogen to plasmin → dissolves formed clot. Fibrin-selective.

Recombinant tissue plasminogen activator variant (fibrinolytic)

Bioengineered tPA with greater fibrin specificity, longer half-life, and PAI-1 resistance → single-bolus dosing.

Education only — not a substitute for current package inserts or clinical judgment. Always confirm doses.