/reference/drugs/ob-gyn

OB / GYN Related

Oxytocin, methylergonovine, carboprost, terbutaline, mag sulfate

Oxytocin

Pitocin

Endogenous nonapeptide / uterotonic

Stimulates uterine smooth muscle contraction (uterine OXTR receptors). ADH-like action at high doses.

Carboprost (Hemabate)

Hemabate · 15-methyl PGF2α

Synthetic prostaglandin F2α analog (uterotonic)

15-methylated synthetic analog of prostaglandin F2α. Binds prostaglandin F receptors on uterine smooth muscle → potent contraction. Also constricts pulmonary smooth muscle → BRONCHOSPASM (contraindication in asthma).

Methylergonovine (Methergine)

Methergine

Ergot alkaloid uterotonic (semi-synthetic)

Direct uterine smooth muscle stimulant — potent + sustained contraction. Also vasoconstrictor (especially coronary + cerebral arteries) → CONTRAINDICATED in HTN, preeclampsia, CAD.

Misoprostol (Cytotec)

Cytotec

Synthetic prostaglandin E1 analog (uterotonic + cytoprotective)

Synthetic PGE1 analog. Binds prostaglandin E receptors on uterine smooth muscle → contraction. Also: cytoprotective gastric mucosa (original indication for NSAID-induced ulcers); cervical ripening; GI motility.

Education only — not a substitute for current package inserts or clinical judgment. Always confirm doses.