Driving pressure (Pplat − PEEP)

Driving pressure is the strongest single mortality predictor in ARDS (Amato et al. NEJM 2015). Target <15 cmH₂O.

Plateau pressure (cmH₂O)PEEP (cmH₂O)

Driving pressure

17 cmH₂O

↑ Above target — consider lowering TV or recruiting + raising PEEP to lower plateau.

Driving P = 25 − 8 = 17 cmH₂O
Target <14-15 (Amato et al. NEJM 2015 — driving pressure best mortality predictor in ARDS)