Ropivacaine
Naropin
Amide local anesthetic, long-acting
S-enantiomer of propivacaine. Less lipid-soluble than bupivacaine → less cardiotoxicity but slightly less potency.
Indications
- •Peripheral nerve blocks
- •Epidural
- •Wound infiltration
Dosing
| Context | Adult | Pediatric |
|---|---|---|
| Epidural | 0.2–0.5% bolus; 0.1–0.2% infusion | — |
| Peripheral block | 0.5–0.75% 20–40 mL | — |
| Local infiltration | Max 3 mg/kg plain | — |
Pharmacokinetics
Onset 5–15 min. Duration 4–8 h. Hepatic CYP1A2 + CYP3A4.
Side effects
- !LAST (less than bupivacaine but still possible)
- !Motor-sparing at low concentrations (useful for OB labor + ambulatory)
Contraindications
- ×Bier block
Clinical pearls
- ★Better motor/sensory differential than bupivacaine — preferred for labor epidurals at 0.0625–0.1%.
- ★Slightly less potent than bupivacaine — may need 1.2–1.5× dose for equivalent block.
Education only — confirm against current package inserts and institutional protocols. Doses assume normal organ function unless otherwise noted.