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Brachial Plexus Blocks — Interscalene, Supraclav, Infraclav, Axillary + Phrenic-Sparing
TEXTRegional · 8 min read
Four approaches, one plexus. Pick the level that matches the surgery and the patient's pulmonary reserve. The phrenic nerve is the recurring villain.
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4 min read7 sectionsBrachial plexus anatomy — roots to terminal branches
Roots (C5-T1) trunks (upper, middle, lower) at interscalene groove divisions (anterior, posterior) behind clavicle cords (lateral, posterior, medial) lateral to first rib + medial to coracoid terminal branches (musculocutaneous, axillary, radial, median, ulnar) at axilla.
Mnemonic: Real Texans Drink Cold Beer (Roots, Trunks, Divisions, Cords, Branches).
- musculocutaneous (lateral forearm sensory, biceps motor — branches off lateral cord above axilla)
- axillary (deltoid + shoulder skin — branches off posterior cord proximal)
- radial (posterior arm + dorsal hand)
- median (palmar lateral 3.5 digits + thenar)
- ulnar (medial 1.5 digits + hypothenar + interossei)
Block level determines which branches are reliably captured.

Interscalene block — shoulder + proximal humerus
Sonoanatomy: 'stoplight' sign — three round hypoechoic structures (C5, C6 upper trunk, C7) between scalene muscles.
- shoulder arthroscopy
- total shoulder
- clavicle (distal third)
- proximal humerus
SPARES ulnar nerve (C8-T1) — unreliable for forearm/hand surgery.
Volume: 10-20 mL ropi 0.5% or bupi 0.5%.
Hallmark complication: 100% PHRENIC NERVE PARALYSIS at full volume — diaphragm paralysis lasts duration of block (10-24 hr); 25-30% FVC reduction.
CONTRAINDICATED in severe COPD, severe restrictive lung disease, contralateral diaphragm paralysis, contralateral pneumothorax.
- Horner syndrome (sympathetic chain)
- recurrent laryngeal nerve block (hoarseness — bilateral block contraindicated)
- vertebral artery injection (immediate seizure)
- epidural/intrathecal spread
- pneumothorax (rare with US)

Phrenic-sparing variants of interscalene
For shoulder surgery in patients with marginal pulmonary reserve where interscalene is otherwise indicated: (1) Low-volume interscalene 5-7 mL at exact target — reduces phrenic paralysis to ~40-60% while preserving shoulder analgesia.
Choose based on duration + density needed.

Supraclavicular block — the 'spinal of the arm'
Sonoanatomy: 'cluster of grapes' — hypoechoic plexus lateral + superficial to pulsing subclavian artery, with hyperechoic first rib + pleura immediately deep.
- arm
- forearm
- elbow
- hand surgery — densest
- fastest
- most complete block of the brachial plexus
Volume: 20-25 mL ropi 0.5% or bupi 0.5%.
Phrenic paralysis 50-67% (less than interscalene because phrenic-bound fibers have already left at this level).
Pneumothorax was the historic feared complication (1-6% pre-US era); modern US-guided rates <0.5%.
Use the first rib as a hyperechoic backstop — keep needle tip above + lateral to rib, never aim medially toward dome of pleura.
- Horner syndrome (~30%)
- subclavian arterial puncture
- hoarseness

Infraclavicular block — cords at coracoid
Sonoanatomy: pulsing axillary artery at depth 3-5 cm; cords appear as hyperechoic 'wedges' at 9 o'clock (lateral), 6 o'clock (posterior), 3 o'clock (medial) positions.
Volume: 20-30 mL deposited posterior to artery first ('U-shape' spread).
Patient can keep arm at side.
- deeper block — harder needle visualization
- more uncomfortable insertion
- contraindicated with pacemaker over chest in the path of needle
Preferred for COPD patients needing forearm surgery.

Axillary block — terminal branches at axilla
- median
- ulnar
- radial nerves (perivascular at axillary artery) + musculocutaneous (in coracobrachialis muscle separately)
Sonoanatomy: axillary artery + vein at 3-5 cm depth in axilla; median at 10-12 o'clock, ulnar at 6 o'clock, radial at 6-8 o'clock posterior to artery.
Volume: 5-7 mL per nerve + separate 5-7 mL into coracobrachialis for musculocutaneous = ~25-30 mL total.
Failure rate higher than supraclav unless musculocutaneous separately injected (musculocutaneous leaves the sheath above axilla and is missed by trans-sheath injection).
The axillary approach is the right answer for COPD patient needing hand surgery.

Local anesthetic dosing + toxicity
2 mg/kg plain, 3 mg/kg with epinephrine3 mg/kg4.5 mg/kg plain, 7 mg/kg with epinephrineA 70 kg patient receiving 30 mL of bupivacaine 0.5% (150 mg = 2.1 mg/kg) is near the limit — for higher-volume blocks (supraclav + intercostobrachial supplement), dilute to 0.375% or split between agents.
- lidocaine
5-10 min - ropi
15-25 min - bupi
15-30 min
- lidocaine
2-4 hr - ropi
8-14 hr - bupi
8-16 hr(longer with epi)
- STOP injection
- 100% O2
- call for help
- benzodiazepine for seizure
- lipid emulsion 20%
1.5 mL/kgbolus +0.25 mL/kg/mininfusion - ACLS with reduced epinephrine doses (1 mcg/kg boluses, NOT 1 mg)

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